The Heart and Vascular Institute

Clinical Trials Currently Enrolling Participants

St. Anthony’s physicians and staff regularly work with patients who opt to participate in clinical trials designed to test the effects of medications, medical devices and care protocols in the treatment of heart disorders and diseases. All clinical trials are overseen by a cardiologist, vascular surgeon, neurologist, a neurosurgeon or an interventional radiologist approved by Western Institutional Review Board, a centralized clinical trials review board, and coordinated by a St. Anthony’s Clinical Research Coordinator.

Ongoing Clinical Research Trials:

RE-DUAL: A trial for patients with Non-valvular Atrial Fibrillation undergoing Percutaneous Coronary Intervention (PCI) with stenting.  The trial is looking to compare anti-platelet therapies: two medications versus three medications following PCI.  Participants are randomized to either dual antiplatelet therapy (dabigatran + clopidogrel or ticagrelor) or triple antiplatelet therapy (warfarin + aspirin + clopidogrel or ticagrelor) and followed for 2-3 years.

VOYAGER: A trial for patients with peripheral arterial disease who will need or recently had a revascularization procedure.  It is looking to study whether xarelto added to aspirin is superior to aspirin alone in reducing the risk of blood clots.  Patients are randomized to xarelto + aspirin or to placebo + aspirin and followed for approximately 3 years.

WRAP-IT: World-wide Randomized Antibiotic EnveloPe Infection prevention Trial: A study looking at the effectiveness of a Medtronic TYRX envelope to reduce infection rates with the placement of a Cardiovascular Implantable Electronic Device (CIED).  Patients are randomized to either receive or not receive the TRYX absorbable antibiotic envelope upon placement of a new Medtronic CIED or the upgrade, revision, or generator change in an existing Medtronic device and followed for 2 years.

MaRISS: Mild and Rapidly Improving Stroke Study:  A study following patients who have had a mild stroke or a rapidly improving stroke due to a blood clot to assess quality of life and abilities at 1 and 3 months after hospital discharge. 

ARAMIS: Addressing Real-world Anticoagulant Management Issues in Stroke: A registry established to document current treatment patterns and outcomes of patients who have had stroke due to a clot or a bleed.  Patients are contacted by phone following hospital discharge at 3 and 6 months.

For information about these and other clinical trials at St. Anthony’s, please contact our Clinical Research Coordinator at 314-525-1697

Clinical Trials in follow-up phase:

GREAT Registry: A Registry which will collect data and information on patients who are treated with a currently approved and used device to treat aortic aneurysms.  Patients will be followed for 10 years, collecting information from visits and CT Scans that would normally be completed by the implanting surgeon. The Registry will collect information on safety and effectiveness of the current device.
Participants will be followed for up to 10 years.

ARTEMIS: Affordability and Real-World antiplatelet Treatment Effectiveness after Myocardial Infarction Study: An economic study to examine the patient’s compliance with taking medication and the doctor’s frequency of  prescribing medication if cost were not a factor following a heart attack.
Participants will be followed for up to 5 years.

ODYSSEY: A randomized, double-blind, placebo controlled, parallel-group study to evaluate the effect of Alirocumab on the occurrence of cardiovascular events in patients who have recently experienced an acute coronary syndrome. Alirocumab is an injectable monoclonal antibody for decreasing LDL cholesterol and cardiovascular events.
Participants will be followed for up to 5 years.

ABSORB III: A clinical evaluation of Absorb BVS, the Everolimus eluting bioreabsorbable vascular scaffold in the treatment of subjects with de novo native coronary artery lesions.
Participants will be followed for up to 5 years.

GORE IBE: Evaluation of the Gore Excluder Iliac Branch Endoprosthesis for the Treatment of common iliac artery aneurysms or aorto-iliac a neurysms.
Participants will be followed for up to 5 years.

Related Upcoming Events

Sep
25

CPR for Family and Friends: Infants and Children
Monday, 6:00 PM to 9:00 PM

Oct
02

CPR for Family and Friends: Infants and Children
Monday, 6:00 PM to 9:00 PM

Oct
28

Heartsaver AED CPR
Saturday, 8:00 AM to 12:30 PM

Nov
02

CPR for Family and Friends: Infants and Children
Thursday, 6:00 PM to 9:00 PM

Dec
07

CPR for Family and Friends: Infants and Children
Thursday, 6:00 PM to 9:00 PM